Senior Assist. Prof. PhD Maya Guncheva
address: G. Bonchev, bl. 9, fl. 4, room 408
E-mail: maiag@orgchm.bas.bg
Phone: + 359 2 960 6 160
Work experience
Jan. 2003 - Oct. 2004
Institute of Organic Chemistry with Centre of Phytochemistry at Bulgarian Academy of Sciences
Chemist
Nov. 2004 - until now
Institute of Organic Chemistry with Centre of Phytochemistry at Bulgarian Academy of Sciences
Senior Assist. Prof.
Education
1994 - 1999
Faculty of Chemistry ат University of Sofia "St. Kl. Ohridski"
Organic and analytical chemistry
M.Sc.
2000 - 2004
Institute of Organic Chemistry with Centre of Phytochemistry at Bulgarian Academy of Sciences
Biooorganic chemistry, chemistry of natural and physiologically active compounds
PhD
Key words
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Biocatalysis
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Enzyme and protein stabilization
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Organic synthesis
Expert activities
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Editorial board member of American Journal of Life Sciences;
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Reviewer for peer-reviewed journals in the field of biocatalysis and applied enzymology
2010 - present
Significant publications
1. Guncheva M., Paunova K., Dimitrov M., Yancheva D. Stabilization of Candida rugosa lipase on nanosized zirconia-based materials. (2014) J. Mol. Cat. B:Enzym. 108, pp. 43–50
2. Guncheva M., Dimitrov M., Napoly F., Draye М., Andrioletti B. Novel Hybrid Materials on the Basis of Nanostructured Tin Dioxide and a Lipase from Rhizopus delemar with Improved Enantioselectivity. (2014) J. Mol. Cat. B: Enzym. 102, pp. 72 – 80
3. Guncheva M., Zhiryakova D. Catalytic properties and potential applications of Bacillus lipases (Review) (2011) J. Mol. Cat. B: Enzym.68 (1), pp. 1-21.
4. Zhiryakova, D., Ivanov, I., Ilieva, S., Guncheva, M., Galunsky, B., Stambolieva, N. Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center?: Supporting amino acid residues at the active site of penicillin G acylase. (2009) FEBS Journal 276, pp. 2589–2598.
5. Guncheva, M., Ivanov, I., Galunsky, B., Stambolieva, N., Kaneti J. Kinetic studies and molecular modeling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263. (2004) Eur. J. Biochem. 271, pp. 2272 - 2279
2010 - present
Significant projects
1. Stabilization of Candida rugosa lipase on nanosized zirconia-based materials - project number: BG051PO001-3.3.05.0001, Dr. Maya Guncheva, PI, 2014 -2014
Ministry of Education and Science, Programme “Science – Business”
2. Excellent stability and synthetic activity of immobilized on tin dioxide lipase from B. stearothermophilus MC7 - project number: BG051PO001-3.3.05.0001, Dr. Maya Guncheva, PI, 2013 -2013
Ministry of Education and Science, Programme “Science – Business”
3. New nanocomposites on the basis of mesoporous supports with potential application for solving some ecology problems and in biocatalysis, project number: DMU 02/50, Dr. Maya Guncheva, team leader, 2009 – 2012
National Science Fund of Bulgaria
4. Regiospecific synthesis of structured lipids for food and medicine catalysed by immobilized lipase from B. Stearothermophilus MC7, project number: MU-X-1501, Dr. Maya Guncheva, PI, 2005 – 2008
National Science Fund of Bulgaria